Synthesis of 6,7-Dihydroindazole and 7,8-Dihydroquinazoline Derivatives from Ethyl 4,4-Dimethyl-9-oxo-3,4-dihydro-9H-xanthene-2-carboxylates

A procedure has been developed for the synthesis of 6,7-dihydroindazoles and 7,8-dihydroquinazolines by reaction of 3,4-dihydroxanthone derivatives with 1,2- and 1,3-binucleophiles (hydrazine, guanidine). The reaction occurred under mild conditions (methanol, 20-65 degrees C) with high yields.

Automated summary

A method has been developed for synthesizing 6,7-dihydroindazoles and 7,8-dihydroquinazolines by reacting 3,4-dihydroxanthone derivatives with 1,2- and 1,3-binucleophiles (hydrazine, guanidine) under mild conditions (methanol, 20-65 degrees C) with high yields.