Complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) as an inhibitor of the acid lipase of the aortic intima

The previously unknown ability of Zitrimin, the complex of tris(2-hydroxyethyl)amine with zinc(ii) bis(2-methylphenoxyacetate), to affect the activity of acid lipase of the aortic intima was studied. Daily administration of an aqueous solution of the tris(2-hydroxyethyl)amine complex with zinc bis(2-methylphenoxyacetate) in a dose of 10 mg kg(-1) for 3 months to rabbilts with experimental atherosclerosis was found to decrease the cholesterol and total lipid levels in the aortic tissue and to decrease the degree of aortic damage with atherosclerotic plaques. According to the results of enzymatic analysis, development of atherosclerosis is accompanied by 68% increase in the activity of acid lipase in the intima of the aorta compared to the control.

Automated summary

Zitrimin has the previously unknown ability to decrease cholesterol and total lipid levels in aortic tissue and reduce aortic damage with atherosclerotic plaques. The development of atherosclerosis is associated with an increase in acid lipase activity in the aortic intima.