3.9 Review

Ocular complications induced during dupilumab treatment of atopic dermatitis

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Atopic dermatitis displays stable and dynamic skin transcriptome signatures

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Summary: Skin transcriptome studies in atopic dermatitis have shown core features of disturbed epidermal differentiation and IL-31/IL-1 signaling activation, along with type 2 inflammation, T(H)17 signaling, and natural killer cell function. IL4RA is a key dysregulated gene, and cyclosporine and dupilumab have distinct effects on the transcriptome in AD patients.

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Summary: This study evaluated a consecutive case series of patients with Dupilumab-associated ocular surface disease (DAOSD), describing common ocular symptoms and signs, proposing a symptom-based grading system, and highlighting the efficacy of treatments like topical corticosteroids. By utilizing a symptom-based grading scale, the study provides insights for nonophthalmic physicians to guide ophthalmology consultations.

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