4.4 Article

Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat

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Summary: The study on prenatal developmental toxicity of bitumen fume in rats showed dose-related effects on body weight and organs, with a maternal NOAEL of 52 mg/m(3). High-dose exposure resulted in treatment-related effects on body weight, food consumption, lung weights, and histopathological changes in lungs and larynx. However, fetal anomalies were not induced even at the highest concentration of 482 mg/m(3).

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