期刊
REGENERATIVE MEDICINE
卷 16, 期 6, 页码 567-579出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2020-0096
关键词
axon regeneration; cellular processes; CNS; cranial nerve; nerve injury; PNS
The process of cranial nerve regeneration remains largely unknown, and future research should continue to focus on elucidating the mechanisms of cranial nerve regeneration, as well as the cellular interactions, molecules, and pathways involved.
There exists a dichotomy in regenerative capacity between the PNS and CNS, which poses the question - where do cranial nerves fall? Through the discussion of the various cells and processes involved in axonal regeneration, we will evaluate whether the assumption that cranial nerve regeneration is analogous to peripheral nerve regeneration is valid. It is evident from this review that much remains to be clarified regarding both PNS and CNS regeneration. Furthermore, it is not clear if cranial nerves follow the PNS model, CNS model or possess an alternative novel regenerative process altogether. Future research should continue to focus on elucidating how cranial nerves regenerate; and the various cellular interactions, molecules and pathways involved.
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