期刊
RECORDS OF NATURAL PRODUCTS
卷 16, 期 1, 页码 58-65出版社
ACG PUBLICATIONS
DOI: 10.25135/rnp.261.21.04.2050
关键词
Clusiaceae; Calophyllum pisiferum; 4-phenyl coumarin; xanthone; cytotoxic
This study represents the first phytochemical investigation of the roots of Calophyllum pisiferum Planch. & Triana. Two new compounds, calopisifuran and 1-hydroxy-4,5-dimethoxyxanthone, were isolated and identified, along with 11 known compounds. The isolated compounds showed significant cytotoxic activity and weak antioxidant activity.
This is the first phytochemical investigation of the roots of Calophyllum pisiferum Planch. & Triana. A new 4-phenyl coumarin, calopisifuran (1), and a new xanthone, 1-hydroxy-4,5-dimethoxyxanthone (2), were isolated and identified, together with 11 known compounds, including 4-phenyl coumarin (3.7) and xanthones (8.13). Their structures were elucidated by 1D- and 2D-NMR spectra and by HR-ESI-QTOF mass spectra and were compared with the literature data for known compounds. The isolated compounds exhibited significant cytotoxic activity in the MDA-MB-231, MCF-7 and A-549 cell lines, with IC50 values of 14.87, 23.56 and 43.34 mu g/mL, respectively, for 10 and IC50 values of 17.15, 45.76 and 85.17 mu g/mL, respectively, for 1, while the DPPH assay revealed weak antioxidant activity.
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