Polarized hydroxyapatite/BaTiO3 scaffolds with bio-inspired porous structure for enhanced bone penetration

The porous HA/BaTiO3 ceramics have the potential to exhibit superior capabilities to promote bone in-growth. However, there are few reports on in vivo studies. Here, we fabricated bio-inspired porous HA/BaTiO3 composites for bone repair via freeze-casting. These composites had a unique microstructure composed of the central canal and radically distributed lamellae, similar to the structure of nature cortical bone unite, the Haversian system. Polarized and non-polarized bio-inspired porous HA/BaTiO3 samples were implanted into the femoral condyle of the New Zealand rabbits. It was demonstrated that the polarization of the porous HA/BaTiO3 played a favorable part in bone regeneration. Moreover, the combination between the osteoconductivity of the microstructure and augmented osteogenic cell behavior induced by charges on surfaces of polarized porous HA/BaTiO3 facilitated bone penetration through the implants. The bio-inspired porous HA/BaTiO3 composites are demonstrated to be promising scaffolds for bone repair.

Automated summary

Bio-inspired porous HA/BaTiO3 composites fabricated via freeze-casting exhibit the potential to promote bone in-growth. Polarized porous HA/BaTiO3 plays a favorable part in bone regeneration, facilitating bone penetration through the implants. The combination of microstructure osteoconductivity and augmented osteogenic cell behavior induced by polarized porous HA/BaTiO3 surfaces makes them promising scaffolds for bone repair.