期刊
RADIOTHERAPY AND ONCOLOGY
卷 161, 期 -, 页码 47-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2021.05.026
关键词
Radiation pneumonitis; Thoracic radiotherapy; Palliative intent; Interstitial lung disease; UIP
资金
- Japan Agency for Medical Research and Development (AMED) [18ck0106210h0003, 19ck0106485h001]
- Science and Culture of Japan (JSPS KAKENHI) [18K15612]
- National Cancer Center Research and Development Fund [31-A-17]
- Grants-in-Aid for Scientific Research [18K15612] Funding Source: KAKEN
This study investigated the risk of radiation pneumonitis (RP) after palliative radiotherapy in cancer patients with interstitial lung disease. The results showed that ILD pattern was a significant predictive factor for severe RP. Careful administration of radiotherapy involving a lung field to ILD patients is recommended, and evaluation of the ILD pattern on pretreatment CT images may be helpful in treatment decisions.
Purpose: The risk of radiation pneumonitis (RP) after palliative radiotherapy (RT) in cancer patients with interstitial lung disease (ILD) remains unclear. This study aimed to investigate the incidence, severity, and predictive factors of RP among patients with ILD who received palliative RT. Methods and materials: The medical records of cancer patients with ILD who received palliative RT involving a lung field between January 2008 and December 2019 were retrospectively reviewed. Screening for ILD was performed by using the ICD-10 diagnosis code, and the ILD was evaluated on the basis of pretreatment computed tomography (CT). RP was scored using Common Terminology Criteria for Adverse Events, version 5.0. Associations between both clinical and dosimetric factors and RP were assessed by univariate and multivariate analyses. Results: Sixty-two patients were included in the analysis. The median prescribed physical dose of RT was 25 Gy (range, 6-40 Gy). The RP was graded 1, 2, 3, 4, and 5 in 6 (10%), 3 (5%), 1 (2%), 2 (3%), and 6 (10%) patients, respectively. The median time to onset of grade 3 or more RP (>Gr3 RP) was 39 days (range, 10- 155). The results of the multivariate analysis indicated that ILD pattern was a significant predictive factor for >Gr3 RP (odds ratio, 12.0; 95% confidence interval, 1.02-1664; P < 0.05). Conclusions: RT involving a lung field, even when prescribed with palliative intent, should be administered carefully to ILD patients. Evaluation of the ILD pattern on pretreatment CT images may be of help in determining whether to perform RT. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据