Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder

Objective Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM). Methods In the present study, a total of 36 medication naive children with ADHD (aged from 8 to 15 years) and 36 age- and gender-matched healthy control (HC) children were included. The digit span test was used to evaluate WM. The magnetic resonance imaging (MRI) was used to examine the characteristics of cortical morphology. Firstly, we compared the cortical morphology features between two groups to identify the potential structural alterations of cortical volume, surface, thickness, and curvature in children with ADHD. Then, the correlation between the brain structural abnormalities and WM was further explored in children with ADHD. Results Compared with the HC children, the children with ADHD showed reduced cortical volumes in the left lateral superior temporal gyrus (STG) (p =6.67x 10(-6)) and left anterior cingulate cortex (ACC) (p=3.88x10(-4)). In addition, the cortical volume of left lateral SIG was positively correlated with WM (r=0.36, p=0.029). Conclusion Though preliminary, these findings suggest that the reduced cortical volumes of left lateral STC; may contribute to the pathogenesis of ADHD and correlate with WM in children with ADHD.

Automated summary

The study compared cortical morphology features between children with ADHD and healthy controls, finding reduced cortical volumes in the left lateral superior temporal gyrus and left anterior cingulate cortex in children with ADHD. Additionally, the cortical volume of the left lateral STG was positively correlated with working memory in children with ADHD.