4.2 Review

Enzymes for Efficient CO2 Conversion

期刊

PROTEIN JOURNAL
卷 40, 期 4, 页码 489-503

出版社

SPRINGER
DOI: 10.1007/s10930-021-10007-8

关键词

CO2 capture technology; CO2 conversion; Enzymes; Cofactor regeneration; Biocatalysis

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The accumulation of carbon dioxide in the atmosphere due to human activities has resulted in adverse effects worldwide. Proposed solutions to reduce carbon dioxide emissions are valuable, but face challenges due to increasing human activity. Converting released carbon dioxide into different chemicals presents a fundamental solution to the problem, with enzyme-based systems showing promise, particularly through the use of dehydrogenases. Studies have shown the potential for increased industrial capacity in CO2 reduction through the identification and redesign of more active and stable enzymes.
The accumulation of carbon dioxide in the atmosphere as a result of human activities has caused a number of adverse circumstances in the world. For this reason, the proposed solutions lie within the aim of reducing carbon dioxide emissions have been quite valuable. However, as the human activity continues to increase on this planet, the possibility of reducing carbon dioxide emissions decreases with the use of conventional methods. The emergence of compounds than can be used in different fields by converting the released carbon dioxide into different chemicals will construct a fundamental solution to the problem. Although electro-catalysis or photolithography methods have emerged for this purpose, they have not been able to achieve successful results. Alternatively, another proposed solution are enzyme based systems. Among the enzyme-based systems, pyruvate decarboxylase, carbonic anhydrase and dehydrogenases have been the most studied enzymes. Pyruvate dehydrogenase and carbonic anhydrase have either been an expensive method or were incapable of producing the desired result due to the reaction cascade they catalyze. However, the studies reporting the production of industrial chemicals from carbon dioxide using dehydrogenases and in particular, the formate dehydrogenase enzyme, have been remarkable. Moreover, reported studies have shown the existence of more active and stable enzymes, especially the dehydrogenase family that can be identified from the biome. In addition to this, their redesign through protein engineering can have an immense contribution to the increased use of enzyme-based methods in CO2 reduction, resulting in an enormous expansion of the industrial capacity.

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