期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 87, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2021.100994
关键词
Choroid; Choroidal endothelial cell; Chorioretinal disease; Fenestrations; Vascular endothelial growth factor
资金
- Stichting Macula Fonds
- Retina Nederland Onderzoek Fonds
- Stichting BlindenPenning
- Alge-mene Nederlandse Vereniging ter Voorkoming van Blindheid
- Landelijke Stichting voor Blinden en Slechtzienden
- UitZicht
- Rotterdamse Stichting Blindenbelangen
- Stichting Leids Oogheelkundig Ondersteuningsfonds
- Stichting Blind-enhulp
- Stichting Ooglijders
- ZonMw MKMD Grant
- IFER Graduate Fellowship Program
- Health Holland PLURIMACULA Grant
The choroid plays a crucial role in maintaining ocular homeostasis and is involved in various chorioretinal diseases. Recent advances in single-cell RNA sequencing have provided valuable insights into the characteristics of choroidal endothelial cells (CECs).
The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood. Recent advances in the field of single-cell RNA sequencing have yielded valuable insights into the properties of choroidal endothelial cells (CECs). Here, we review the role of the choroid in various physiological and pathophysiological mechanisms, focusing on the role of CECs. We also discuss new insights regarding the phenotypic properties of CECs, CEC subpopulations, and the value of measuring transcriptomics in primary CEC cultures derived from post-mortem eyes. In addition, we discuss key phenotypic, structural, and functional differences that distinguish CECs from other endothelial cells such as retinal vascular endothelial cells. Understanding the specific clinical and molecular properties of the choroid will shed new light on the pathogenesis of the broad clinical range of chorioretinal diseases such as age-related macular degeneration, central serous chorioretinopathy and other diseases within the pachychoroid spectrum, uveitis, and diabetic choroidopathy. Although our knowledge is still relatively limited with respect to the clinical features and molecular pathways that underlie these chorioretinal diseases, we summarise new approaches and discuss future directions for gaining new insights into these sight-threatening diseases and highlight new therapeutic strategies such as pluripotent stem cell-based technologies and gene therapy.
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