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Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis

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PROGRESS IN CARDIOVASCULAR DISEASES
卷 68, 期 -, 页码 70-77

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W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcad.2021.07.005

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Non-coding RNAs; miRNAs; Lnc-RNAs; circRNAs; Biomarkers; Sepsis; Cardiomyopathy; Epigenetics

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This article highlights the importance of non-coding RNAs in mediating mechanisms underlying cardiovascular dysfunction after sepsis, including sepsis-induced cardiomyopathy. Non-coding RNAs are novel regulators of cardiovascular disease risk factors and have the potential to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other cardiovascular events that occur after sepsis.
The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, includ-ing microRNAs, long non-coding RNAs, and circular RNAs, playa crucial role in genetic reprogramming, gene reg-ulation, and inflammation during the development of CVD. Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mech-anisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies. (c) 2021 Elsevier Inc. All rights reserved.

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