期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2024815118
关键词
COVID-19; variants of concern; viral biomass; viral load; genetic diversity
资金
- European Research Council [NOVCARBFIX 646827]
- Israel Science Foundation [740/16]
- Beck-Canadian Center for Alternative Energy Research
- Ullmann Family Foundation
- Helmsley Charitable Foundation
- Larson Charitable Foundation
- Wolfson Family Charitable Trust
- NIH [1R35 GM118043-01]
- Merkin Institute for Translational Research
- Israeli Council for Higher Education via the Weizmann Data Science Research Center
Each infected person carries 10^9 to 10^11 SARS-CoV-2 virions during peak infection, with a total mass in the range of 1-100 micrograms. The study shows that antibodies in infected hosts significantly outnumber spike proteins, and the genetic diversity of virions covers all possible single nucleotide substitutions.
Quantitatively describing the time course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for understanding the current global pandemic and possible ways to combat it. Here we integrate the best current knowledge about the typical viral load of SARS-CoV-2 in bodily fluids and host tissues to estimate the total number and mass of SARS-CoV-2 virions in an infected person. We estimate that each infected person carries 10(9) to 10(11) virions during peak infection, with a total mass in the range of 1 mu g to 100 mu g, which curiously implies that all SARS-CoV-2 virions currently circulating within human hosts have a collective mass of only 0.1 kg to 10 kg. We combine our estimates with the available literature on host immune response and viral mutation rates to demonstrate how antibodies markedly outnumber the spike proteins, and the genetic diversity of virions in an infected host covers all possible single nucleotide substitutions.
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