期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2018840118
关键词
neuropsin (OPN5); myopia; violet light; nonvisual photoreceptors
资金
- (KAKENHI) from the Ministry of Education, Culture, Sports, Science and Technology [18K09424]
- Tsubota Laboratory, Inc. (Tokyo, Japan)
- Rehab RAMP
- D Service, Department of Veterans Affairs [IK6 RX003134]
- National Eye Institute, NIH [EY016435]
Outdoor activity has a protective effect on myopia. Recent research has found that violet light can prevent myopia progression in mice by preventing lens defocus-induced myopia. This suggests a potential strategy for myopia prevention in humans.
Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans.
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