4.8 Article

Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences

Anna Paola Carrieri et al.

Summary: Alterations in the human microbiome have been observed in various conditions, and there is still much to learn about the links between the microbiome and human health. The combination of artificial intelligence and rich microbiome datasets offers a better understanding of the microbiome's role in human health. Using an explainable artificial intelligence approach, predictions of phenotypes can be made from leg skin microbiome samples, providing explanations based on variations in key microbes.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules

Natasha L. Patel-Murray et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation

Yuchen Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Molecular mechanisms of Evening Complex activity in Arabidopsis

Catarina S. Silva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Genetics & Heredity

Opening the Black Box: Interpretable Machine Learning for Geneticists

Christina B. Azodi et al.

TRENDS IN GENETICS (2020)

Review Computer Science, Artificial Intelligence

Drug discovery with explainable artificial intelligence

Jose Jimenez-Luna et al.

NATURE MACHINE INTELLIGENCE (2020)

Article Multidisciplinary Sciences

Evolutionarily informed deep learning methods for predicting relative transcript abundance from DNA sequence

Jacob D. Washburn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Exposure to High-Intensity Light Systemically Induces Micro-Transcriptomic Changes in Arabidopsis thaliana Roots

Barczak-Brzyzek Anna et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

ArrayExpress update - from bulk to single-cell expression data

Awais Athar et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biology

Bootstrapping and Empirical Bayes Methods Improve Rhythm Detection in Sparsely Sampled Data

Alan L. Hutchison et al.

JOURNAL OF BIOLOGICAL RHYTHMS (2018)

Article Medicine, Research & Experimental

High-accuracy determination of internal circadian time from a single blood sample

Nicole Wittenbrink et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

Universal method for robust detection of circadian state from gene expression

Rosemary Braun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals

Marco Preussner et al.

MOLECULAR CELL (2017)

Article Plant Sciences

The G-Box Transcriptional Regulatory Code in Arabidopsis

Daphne Ezer et al.

PLANT PHYSIOLOGY (2017)

Article Multidisciplinary Sciences

A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens

Chen Li et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes

Dina Hafez et al.

GENOME BIOLOGY (2017)

Correction Biochemical Research Methods

What time is it? Deep learning approaches for circadian rhythms (vol 32, pg i8, 2016)

Forest Agostinelli et al.

BIOINFORMATICS (2016)

Article Biochemical Research Methods

Drug-induced adverse events prediction with the LINCS L1000 data

Zichen Wang et al.

BIOINFORMATICS (2016)

Article Biochemical Research Methods

MetaCycle: an integrated R package to evaluate periodicity in large scale data

Gang Wu et al.

BIOINFORMATICS (2016)

Article Biochemical Research Methods

DeepChrome: deep-learning for predicting gene expression from histone modifications

Ritambhara Singh et al.

BIOINFORMATICS (2016)

Article Biochemistry & Molecular Biology

1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana

Carlos Alonso-Blanco et al.

Article Biochemistry & Molecular Biology

ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system

Jacob J. Hughey et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

DanQ: a hybrid convolutional and recurrent deep neural network for quantifying the function of DNA sequences

Daniel Quang et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

Positional distribution of transcription factor binding sites in Arabidopsis thaliana

Chun-Ping Yu et al.

SCIENTIFIC REPORTS (2016)

Article Biochemical Research Methods

Predicting effects of noncoding variants with deep learning-based sequence model

Jian Zhou et al.

NATURE METHODS (2015)

Review Cell Biology

The expanding world of small RNAs in plants

Filipe Borges et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Review Plant Sciences

Circadian regulation of abiotic stress tolerance in plants

Jack Grundy et al.

FRONTIERS IN PLANT SCIENCE (2015)

Article Multidisciplinary Sciences

Strengths and Limitations of Period Estimation Methods for Circadian Data

Tomasz Zielinski et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation

Jean Hausser et al.

GENOME RESEARCH (2013)

Article Plant Sciences

Arabidopsis COLD SHOCK DOMAIN PROTEIN 2 is a negative regulator of cold acclimation

Kentaro Sasaki et al.

NEW PHYTOLOGIST (2013)

Article Multidisciplinary Sciences

Deciphering the rules by which 5′-UTR sequences affect protein expression in yeast

Shlomi Dvir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Predicting cell-type-specific gene expression from regions of open chromatin

Anirudh Natarajan et al.

GENOME RESEARCH (2012)

Article Multidisciplinary Sciences

Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

Florian Spoerl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Genetics & Heredity

Finding MicroRNA Targets in Plants: Current Status and Perspectives

Jiandong Ding et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2012)

Review Plant Sciences

MicroRNA activity in the Arabidopsis male germline

Filipe Borges et al.

JOURNAL OF EXPERIMENTAL BOTANY (2011)

Article Multidisciplinary Sciences

Timing of plant immune responses by a central circadian regulator

Wei Wang et al.

NATURE (2011)

Review Plant Sciences

Molecular Mechanisms Underlying the Arabidopsis Circadian Clock

Norihito Nakamichi

PLANT AND CELL PHYSIOLOGY (2011)

Article Multidisciplinary Sciences

Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined association and linkage mapping

Adnane Nemri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Biotechnology & Applied Microbiology

Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development

Michael F. Covington et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana circadian clock

Zhaojun Ding et al.

PLANT CELL (2007)

Article Biochemistry & Molecular Biology

Predicting gene expression from sequence

MA Beer et al.

Article Biochemical Research Methods

BioOptimizer: a Bayesian scoring function approach to motif discovery

ST Jensen et al.

BIOINFORMATICS (2004)

Article Biochemistry & Molecular Biology

Decoding human regulatory circuits

W Thompson et al.

GENOME RESEARCH (2004)

Article Multidisciplinary Sciences

Enhanced fitness conferred by naturally occurring variation in the circadian clock

TP Michael et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis circadian clocks

A Hall et al.

PLANT CELL (2003)

Article Cell Biology

The role of CCA1 and LHY in the plant circadian clock

RM Green et al.

DEVELOPMENTAL CELL (2002)

Article Biochemistry & Molecular Biology

Photoperiodism: The consistent use of CONSTANS

A Samach et al.

CURRENT BIOLOGY (2001)

Article Multidisciplinary Sciences

Orchestrated transcription of key pathways in Arabidopsis by the circadian clock

SL Harmer et al.

SCIENCE (2000)