4.8 Article

Probabilistic discrimination of relative stimulus features in mice

出版社

NATL ACAD SCIENCES
DOI: 10.1073/pnas.2103952118

关键词

animal behavior; probabilistic modeling; orientation discrimination

资金

  1. RIKEN Brain Science Institute
  2. JSPS (Japan Society for the Promotion of Science) [26290011, 17H06037, C0219129]
  3. Fujitsu collaborative grant
  4. O'Hara Co., Ltd.
  5. Grants-in-Aid for Scientific Research [26290011, 17H06037] Funding Source: KAKEN

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Studies show that mice can solve complex orientation discrimination tasks with choices decoupled from individual stimuli orientations. They also demonstrate typical discrimination acuity of 9 degrees, challenging the common belief that mice are poor visual discriminators. These findings suggest that mice are a useful animal model for studying neural representations of relative categories in perceptual decision-making research.
During perceptual decision-making, the brain encodes the upcoming decision and the stimulus information in a mixed representation. Paradigms suitable for studying decision computations in isolation rely on stimulus comparisons, with choices depending on relative rather than absolute properties of the stimuli. The adoption of tasks requiring relative perceptual judgments in mice would be advantageous in view of the powerful tools available for the dissection of brain circuits. However, whether and how mice can perform a relative visual discrimination task has not yet been fully established. Here, we show that mice can solve a complex orientation discrimination task in which the choices are decoupled from the orientation of individual stimuli. Moreover, we demonstrate a typical discrimination acuity of 9 degrees, challenging the common belief that mice are poor visual discriminators. We reached these conclusions by introducing a probabilistic choice model that explained behavioral strategies in 40 mice and demonstrated that the circularity of the stimulus space is an additional source of choice variability for trials with fixed difficulty. Furthermore, history biases in the model changed with task engagement, demonstrating behavioral sensitivity to the availability of cognitive resources. In conclusion, our results reveal that mice adopt a diverse set of strategies in a task that decouples decision-relevant information from stimulus-specific information, thus demonstrating their usefulness as an animal model for studying neural representations of relative categories in perceptual decisionmaking research.

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