期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2103126118
关键词
Talbot-Lau grating interferometry; microarray anode-structured target; X-ray source; phase-contrast tomography
资金
- Department of Energy, Laboratory Directed Research and Development program at SLAC National Accelerator Laboratory [DEAC0276SF00515]
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under fasttrack Grant [R44EB023284]
The study developed a TLI system with MAAST source, offering high-resolution and tri-contrast X-ray imaging for biomedical applications. Tomography of Drum fish tooth revealed valuable complementary structural information using this method.
Multicontrast X-ray imaging with high resolution and sensitivity using Talbot-Lau interferometry (TLI) offers unique imaging capabilities that are important to a wide range of applications, including the study of morphological features with different physical properties in biological specimens. The conventional X-ray TLI approach relies on an absorption grating to create an array of micrometer-sized X-ray sources, posing numerous limitations, including technical challenges associated with grating fabrication for high-energy operations. We overcome these limitations by developing a TLI system with a microarray anode-structured target (MAAST) source. The MAAST features an array of precisely controlled microstructured metal inserts embedded in a diamond substrate. Using this TLI system, tomography of a Drum fish tooth with high resolution and tri-contrast (absorption, phase, and scattering) reveals useful complementary structural information that is inaccessible otherwise. The results highlight the exceptional capability of high-resolution multicontrast X-ray tomography empowered by the MAAST-based TLI method in biomedical applications.
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