期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2025275118
关键词
CaMKII; PKM zeta; memory schemata; indirect recall; memory updating
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) /Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) , Brazil
Consolidation and reconsolidation are independent memory processes, with consolidation stabilizing new memories and reconsolidation restabilizing memories destabilized during recall. Dopamine couples novelty detection with memory destabilization to determine whether a new recognition trace is associated with an active network.
Consolidation and reconsolidation are independent memory processes. Consolidation stabilizes new memories, whereas reconsolidation restabilizes memories destabilized when reactivated during recall. However, the biological role of the destabilization/reconsolidation cycle is still unknown. It has been hypothesized that reconsolidation links new information with reactivated memories, but some reports suggest that new and old memories are associated through consolidation mechanisms instead. Object-recognition memory (ORM) serves to judge the familiarity of items and is essential for remembering previous events. We took advantage of the fact that ORM consolidation, destabilization, and reconsolidation can be pharmacologically dissociated to demonstrate that, depending on the activation state of hippocampal dopamine D1/D5 receptors, the memory of a novel object presented during recall of the memory of a familiar one can be formed via reconsolidation or consolidation, but only reconsolidation can link them. We also found that recognition memories formed through reconsolidation can be destabilized even if indirectly reactivated. Our results indicate that dopamine couples novelty detection with memory destabilization to determine whether a new recognition trace is associated with an active network and suggest that declarative reminders should be used with caution during reconsolidation-based psychotherapeutic interventions.
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