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A reasoned approach towards administering COVID-19 vaccines to pregnant women

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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

Article Infectious Diseases

The granting of emergency use designation to COVID-19 candidate vaccines: implications for COVID-19 vaccine trials

Jerome Amir Singh et al.

Summary: Developing an effective COVID-19 vaccine is the current top priority globally, with some nations willing to authorize emergency use or conditional approval if there is a compelling reason before the vaccine is licensed. Leading developers of COVID-19 candidate vaccines have applied or intend to apply for emergency authorization. The potential deployment of candidate vaccines before the completion of phase 3 trials could have significant implications for research and pandemic control.

LANCET INFECTIOUS DISEASES (2021)

Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Medicine, General & Internal

Maintaining Safety with SARS-CoV-2 Vaccines

Mariana C. Castells et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

S. F. Lumley et al.

Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Editorial Material Medicine, General & Internal

Vaccinating against covid-19 in people who report allergies

Rebecca E. Glover et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Obstetrics & Gynecology

Professionally responsible coronavirus disease 2019 vaccination counseling of obstetrical and gynecologic patients

Frank A. Chervenak et al.

Summary: This paper discusses how to professionally and responsibly counsel patients who are pregnant, planning to become pregnant, or breastfeeding about COVID-19 vaccination. It addresses major challenges faced in counseling these groups of patients, and provides evidence-based guidance for healthcare providers to empower patients in making informed decisions. It emphasizes the importance of recommending vaccination, addressing vaccine hesitancy, and engaging with communities to build trust and encourage vaccine uptake.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.
Article Medicine, General & Internal

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y. Logunov et al.

Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.

LANCET (2021)

Review Infectious Diseases

What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

Susanne H. Hodgson et al.

Summary: The development of a vaccine for the novel coronavirus is crucial to prevent the spread of the pandemic and reduce disease mortality. The efficacy endpoint is protection against severe disease and death, but evaluating this in phase 3 clinical trials poses challenges.

LANCET INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Public, Environmental & Occupational Health

The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Janssen COVID-19 Vaccine — United States, February 2021

Sara E. Oliver et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Article Obstetrics & Gynecology

Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls

Chelsea A. DeBolt et al.

Summary: Pregnant women with severe and critical COVID-19 are at an increased risk for certain morbidities when compared with nonpregnant women. Despite higher comorbidities in the nonpregnant group, pregnant women had a higher risk for composite morbidity, intubation, mechanical ventilation, and ICU admission. This suggests that pregnancy may be associated with worse outcomes in women with severe and critical COVID-19.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

Article Medicine, General & Internal

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021

Isaac See et al.

Summary: Cases of CVST with thrombocytopenia following Ad26.COV2.S vaccination have been reported in the US, leading to serious outcomes. This case series may provide guidance for clinical management and further investigation into the potential relationship between Ad26.COV2.S vaccine and CVST with thrombocytopenia.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

Ai-ris Y. Collier et al.

Summary: This study assessed the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women, as well as the responses against emerging SARS-CoV-2 variants. The results showed that pregnant, lactating, and nonpregnant women developed antibody and T-cell responses following vaccination, with antibodies transferred to infant cord blood and breast milk. While antibody titers against the B.1.1.7 and B.1.351 variants were reduced, T-cell responses remained against the viral variants.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Letter Medicine, General & Internal

Thromboembolism and the Oxford-AstraZeneca COVID-19 vaccine: side-effect or coincidence?

Soren Dinesen Ostergaard et al.

LANCET (2021)

Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

Article Medicine, General & Internal

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Victoria Jane Hall et al.

Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.

LANCET (2021)

News Item Multidisciplinary Sciences

CORONAVIRUS VARIANTS ARE SPREADING IN INDIA - WHAT SCIENTISTS KNOW SO FAR

Gayathri Vaidyanathan

NATURE (2021)

Article Medicine, General & Internal

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons

Tom T. Shimabukuro et al.

Summary: Preliminary data indicates that there are no obvious safety signals among pregnant women who received mRNA Covid-19 vaccines, but more data is needed for further confirmation. Adverse reactions such as injection-site pain were reported more frequently in pregnant women, but most pregnancies resulted in live births with some cases of preterm birth and small size for gestational age.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Medicine, General & Internal

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

Laith J. Abu-Raddad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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New SARS-CoV-2 Variants - Clinical, Public Health, and Vaccine Implications

Salim S. Abdool Karim et al.

Summary: The emergence of SARS-CoV-2 variants, including B.1.1.7 (VOC-202012/01), 501Y.V2 (B.1.351), and P.1 (B.1.1.28.1), has raised concerns about worsening Covid-19 and potential escape from vaccine-induced immunity.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Medicine, General & Internal

SARS-CoV-2 Infection after Vaccination in Health Care Workers in California

Jocelyn Keehner et al.

Summary: A study showed that while 71% of healthcare workers tested positive for SARS-CoV-2 within 2 weeks after receiving the vaccine, the percentage decreased after the second dose.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Benefits and potential harms of COVID-19 vaccination during pregnancy: evidence summary for patient counseling

E. Kalafat et al.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2021)

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COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program - Kentucky, March 2021

Alyson M. Cavanaugh et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Postvaccination COVID-19 among Healthcare Workers, Israel

Sharon Amit et al.

Summary: Symptoms of COVID-19 can be mistaken for vaccine-related side effects, highlighting the importance of promptly testing for COVID-19 after vaccination. In a study of healthcare workers in Israel, a small percentage developed COVID-19 within 10 days of vaccination, emphasizing the need for vigilance in monitoring post-vaccination symptoms.

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Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates

Prakesh S. Shah et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2020)

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Intensive care unit admissions for pregnant and nonpregnant women with coronavirus disease 2019

Matthew J. Blitz et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2

Audrey Lamouroux et al.

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Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis

E. Ferrazzi et al.

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Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection

David Baud et al.

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Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

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