期刊
POLYMER TESTING
卷 99, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2021.107207
关键词
Chitosan; Pectin; Cyclea Barbata Miers; Membrane; Wound healing
资金
- Postgraduate Department of Chemistry, Universitas Sumatera Utara [20161141021370]
- LPDP [20161141021370]
In this study, pectin derived from Cyclea Barbata Miers was blended with chitosan to create a novel membrane for potential biomedical wound dressing application. The physico-chemical analysis revealed improved thermal stability and rough surface texture of the chitosan/pectin blend membrane, which also showed better wound closure in in-vivo experiments compared to gauze-treated wounds.
In this work, pectin derived from Cyclea Barbata Miers (CBM) was successfully blended with chitosan as a novel membrane and the physico-chemical analysis was investigated. Based on SEM analysis revealed that the chitosan/pectin blended membrane showed a rough surface texture compared to pristine chitosan with smooth and uniform membran. In addition, fourier-transform infrared spectroscopy (FTIR) analysis indicates that chitosan and pectin were successfully crosslinked, meanwhile x-ray diffraction (XRD) analysis found that pectin extracted from CBM exhibited crystalline structure. Thermal analysis based on thermogravimetric analysis (TGA) suggesting that chitosan/pectin blend membrane exhibited significant improvement in the thermal stability with residual mass of 54% at 360 degrees C. Furthermore, swelling degree, water vapor transmission rate (WVTR) and porosity of the chitosan/pectin blend membrane were 266%, 9.68 g/m(2)h, and 64%, respectively. Most importantly, in-vivo results indicated that the prepared membrane of chitosan/pectin immobilized with Musa Paradisiaca Linn (MPL) group had better wound closure with better wound reduction percentage than the gauze-treated wound (the control group). This finding revealed that the chitosan/pectin blend membrane could paves the way for future biomedical wound dressing application.
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