Preparation and characterization of methylene bisacrylamide crosslinked pectin/acrylamide hydrogels

By manufacturing a pH-sensitive and biocompatible interpenetrating polymer network device, the targeting of BCS III drugs in the colon and improving their absorption can be achieved. Using N, N methylene bisacrylamide as a crosslinker and ammonium persulfate as an initiator, the formed hydrogel was evaluated using an in vitro and in vivo toxicity study of pectin-acrylamide fabricated hydrogels. Fourier transform infrared confirmed the fabrication of stable pectin/acrylamide hydrogel. Swelling studies have shown that swelling is preferably increased by increasing the acrylamide content of hydrogel structures in solutions of higher pH 7.5. For the formulated formulations, porosity and sol-gel fraction were also calculated. With a rise in pectin and acrylamide content, porosity and gel fraction increased, while porosity decreased and gel fraction improved with an increase in N, N methylene bisacrylamide content. At different pH strengths of 1.2, 5.5 and 7.5, the drug release profile was also analysed. With the increasing pH of the dissolution medium, maximum drug release was seen. By fitting experimental data to model equations and determining the corresponding parameters, the release mechanisms were studied. The maximum drug release of 90% was observed in the A6 formulation. The findings showed that the kinetics of drug release from the hydrogels in the respective buffer solutions were mainly due to Fickian diffusion. The in vivo toxicity studies confirmed the safety of the prepared hydrogels and showed no toxicity.

Automated summary

By manufacturing a pH-sensitive and biocompatible interpenetrating polymer network device, the targeting and absorption enhancement of BCS III drugs in the colon can be achieved. The porosity and gel fraction of the hydrogel were related to the content of pectin and acrylamide, and the drug release mechanism was mainly Fickian diffusion.