4.5 Article

Clindamycin-loaded nanofibers of polylactic acid, elastin and gelatin for use in tissue engineering

期刊

POLYMER BULLETIN
卷 79, 期 7, 页码 5495-5513

出版社

SPRINGER
DOI: 10.1007/s00289-021-03734-6

关键词

-

向作者/读者索取更多资源

The polylactic acid, elastin, and gelatin fibers prepared in this study, containing clindamycin, showed homogeneous morphology and demonstrated good antimicrobial effects and cell adhesion properties in release studies and feasibility tests.
In the present work, polylactic acid (PLA), elastin and gelatin fibers, containing clindamycin, were prepared to test their potential application as wound dressings. They underwent release studies to determine the mechanism of drug release through mathematical models. The fibers have a homogeneous morphology, without pores. The studies of FTIR and thermal analysis corroborate the presence of each of the components in the fibers; the results of the feasibility tests showed encouraging percentages with a viability of 82% after 7 days of direct contact of the HUVEC cells with the membranes. Similarly, cell adhesion assays show the presence of viable and stretched cells on the fibers, the tendency of the cells to position themselves on the fibers and follow this conformation was observed. On the other hand, studies of antimicrobial activity against S. aureus show us that in fibers loaded with clindamycin they have inhibition halos greater than 8 mm.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据