Minireview: Remdesivir, A Prominent Nucleotide/Nucleoside Antiviral Drug

Nucleotide analogues are the divergent scaffolds that are reliable potential therapeutic drugs to treat the wide range of diseases including viral infections. For instance, Remdesivir is a biologically important nucleotide analogue prodrug that can act as a key drug target for the diseases Ebola and COVID-19. Remdesivir is a structurally chiral aryloxy-phosphoramidate prodrug as it is metabolized into nucleoside triphosphate (active drug form) inside the cell through sequential reactions by ester mediated-hydrolysis. Thus, the current minireview focuses on the earlier reported synthetic approaches of key fragments of remdesivir and their developments to attain the scale-up yields of the drug for clinical/commercial applies. Further, this review serves as a template for the design and development of other complex organic molecules.

Automated summary

Nucleotide analogues are reliable potential therapeutic drugs for a wide range of diseases, with Remdesivir serving as an important prodrug that can act as a key drug target for diseases such as Ebola and COVID-19. These drugs are metabolized into active drug forms through sequential reactions inside the cell.