期刊
PLOS ONE
卷 16, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0252958
关键词
-
资金
- Alzheimer's Drug Discovery Foundation [20130805]
The study found that individuals with MCI or AD show mild impairment in spatial IOR, which can be detected using a double cue paradigm. Reduced spatial IOR in high-risk healthy older individuals is associated with decreased memory and other neurocognitive task performance.
Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here with a group of older adults (n = 56, 58-80 (67.9 +/- 5.2) year old, 31 females, 18.7 +/- 3.6 years of education), we provide evidence supporting the notion that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), and the impairment is detectable using a double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the double cue spatial IOR paradigm may be useful in detecting MCI and early AD.
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