期刊
PLANTA MEDICA
卷 88, 期 12, 页码 1020-1025出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1542-8992
关键词
curcumin; turmeric; health; ovary; proliferation; apoptosis; hormone; fecundity
资金
- Slovak Research and Development Agency (APVV) [APVV-15-0296]
- Scientific Grant Agency of the Ministry of Education, Science, and Sport of Slovak Republic (VEGA) [VEGA 13-ENV1321-02]
Curcumin affects female reproductive processes by altering the release and reception of hormones, growth factors, and cytokines, as well as influencing ovarian cell response to these substances and external environmental factors. This suggests its potential for stimulating female reproductive processes and treating various reproductive disorders.
The present review summarizes the available knowledge concerning the action of curcumin, the best-known polyphenol among the rhizomes of Curcumas, on female reproductive processes and their dysfunctions. Curcumin affects a number of physiological processes, including female reproduction (puberty, reproductive aging, ovarian follicullogenesis and oogenesis, and fecundity). Curcumin can affect these processes via changes in the release and reception of pituitary and ovarian hormones, growth factors and cytokines. Furthermore, it can influence the response of ovarian cells to these substances and external environmental factors. Finally, curcumin can affect oxidative processes within the ovary and numerous intracellular signalling pathways related to ovarian cell proliferation and apoptosis. These effects suggest the applicability of curcumin for stimulation of female reproductive processes in vivo and in vitro , as well as for the prevention, mitigation, and treatment of various reproductive disorders from ovarian insufficiency and infertility to polycystic ovarian syndrome and ovarian cancer.
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