4.8 Article

Autophagy during drought: function, regulation, and potential application

期刊

PLANT JOURNAL
卷 109, 期 2, 页码 390-401

出版社

WILEY
DOI: 10.1111/tpj.15481

关键词

autophagy; drought; crop; abscisic acid; aquaporin; hormones

资金

  1. National Science Foundation Plant Genome Research Program [1444339]
  2. Iowa State University Walter E. and Helen Parke Loomis fund
  3. Direct For Biological Sciences
  4. Division Of Integrative Organismal Systems [1444339] Funding Source: National Science Foundation

向作者/读者索取更多资源

Drought poses a major challenge for agricultural production, but autophagy plays a crucial role in helping plants survive drought stress by regulating water permeability, degrading toxic proteins, and promoting stress responses. The activation of autophagy through transcriptional and post-translational mechanisms may offer promising strategies for enhancing drought tolerance in plants.
Drought is a major challenge for agricultural production since it causes substantial yield reduction and economic loss. Autophagy is a subcellular degradation and recycling pathway that functions in plant development and responses to many stresses, including drought. In this review, we summarize the current understanding of the function of autophagy and how autophagy is upregulated during drought stress. Autophagy helps plants to survive drought stress, and the mechanistic basis for this is beginning to be elucidated. Autophagy can selectively degrade aquaporins to adjust water permeability, and also degrades excess heme and damaged proteins to reduce their toxicity. In addition, autophagy can degrade regulators or components of hormone signaling pathways to promote stress responses. During drought recovery, autophagy degrades drought-induced proteins to reset the cell status. Autophagy is activated by multiple mechanisms during drought stress. Several transcription factors are induced by drought to upregulate autophagy-related gene expression, and autophagy is also regulated post-translationally through protein modification and stability. Based on these observations, manipulation of autophagy activity may be a promising approach for conferring drought tolerance in plants.

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