期刊
PLACENTA
卷 113, 期 -, 页码 57-66出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2021.05.002
关键词
Syncytiotrophoblast; Stress; Preeclampsia; Placenta
资金
- Agencia Nacional de Investigacion y Desarrollo (ANID) (FONDECYT) [1180935, 3200829]
- CONICYT, PAI Convocatoria Nacional Subvencion a Instalacion en la Academia, Convocatoria Ano 2019 [PAI77190060]
- Secretaria de Investigacion y Posgrado (SIP) of Instituto Politecnico Nacional, Mexico [SIP 20211345, SIP 20211354]
- Biomedical Research Centre, Universidad de Valparaiso, Chile [CI 05/2006]
Preeclampsia is a pregnancy-specific syndrome characterized by sudden increase in blood pressure and poor fetal outcomes. Syncytiotrophoblast stress in early-onset preeclampsia leads to characteristic symptoms, which can be targeted for therapeutic management aiming to improve maternal and fetal outcomes.
Preeclampsia is a pregnancy-specific syndrome characterized by a sudden increase in blood pressure accompanied by proteinuria and/or maternal multi-system damage associated to poor fetal outcome. In early-onset preeclampsia, utero-placental perfusion is altered, causing constant and progressive damage to the syncytiotrophoblast, generating syncytiotrophoblast stress. The latter leads to the detachment and release of syncytiotrophoblast fragments, anti-angiogenic factors and pro-inflammatory molecules into maternal circulation, resulting in the emergence and persistence of the characteristic symptoms of this syndrome during pregnancy. Therefore, understanding the origin and consequences of syncytiotrophoblast stress in preeclampsia is vital to develop new therapeutic alternatives, focused on reducing the burden of this syndrome. In this review, we describe five central characteristics of syncytial stress that should be targeted or prevented in order to reduce preeclampsia symptoms: histological alterations, syncytiotrophoblast damage, antiangiogenic protein export, placental deportation, and altered syncytiotrophoblast turnover. Therapeutic management of these characteristics may improve maternal and fetal outcomes.
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