期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 12, 页码 6489-6513出版社
WILEY
DOI: 10.1002/ptr.7224
关键词
anti-inflammatory; antinociceptive; Curcuma longa; curcumin; pain; turmeric
资金
- Mashhad University of Medical Sciences
Turmeric and its active constituent, curcumin, possess anti-inflammatory, antinociceptive, and antioxidant effects, making them potentially effective in preventing and treating inflammatory disorders and pain. While literature and patents support their clinical application, further high-quality studies are needed to establish their clinical efficacy.
Turmeric (Curcuma longa) and its constituent, curcumin, have been used for their therapeutic properties for a long time. Most of the medicinal impacts of turmeric and curcumin might be attributed to their anti-inflammatory, antinociceptive, and antioxidant effects. In the present review, the preventive and therapeutic potentials of turmeric and its active constituent, curcumin, on inflammatory disorders and pain as well as patents related to their analgesic and anti-inflammatory effects, have been summarized to highlight their value on human health. A literature review was accomplished in Google Scholar, PubMed, Scopus, Google Patent, Patentscope, and US Patent. Several documents and patents disclosed the significance of turmeric and curcumin to apply in several therapeutic, medicinal, and pharmaceutical fields. These phytocompounds could be applied as a supplementary therapy in phytotherapy, inflammatory disorders such as arthritis, inflammatory bowel diseases, osteoarthritis, psoriasis, dermatitis, and different types of pain including neuropathic pain. However, because of inadequate clinical trials, further high-quality studies are needed to firmly establish the clinical efficacy of the plant. Consistent with the human tendency to the usage of phytocompounds rather than synthetic drugs, particular consideration must be dedicated to bond the worth of turmeric and curcumin from basic sciences to clinical applications.
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