期刊
PHYTOCHEMISTRY
卷 187, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.112770
关键词
Carthamus tinctorius; Compositae; Polyacetylene glucosides; Structure elucidation; Anti-inflammatory activity
资金
- National Natural Science Foundation of China (NNSFC) [82022072, U19A2010]
- Ten Thousand Talents Plan of Sichuan Province [168]
- Xinglin Scholar Plan of Chengdu University of Traditional Chinese Medicine [YXRC2018005, BSH2018009, BSH2019028, QNXZ2019030]
Five new polyacetylene glucosides were isolated from the florets of Carthamus tinctorius L., with one showing significant inhibitory effects on nitric oxide production.
Five previously undescribed polyacetylene glucosides, namely, four C-10- and one C-14-acetylenes, together with three known analogues, were isolated from the florets of Carthamus tinctorius L. The structures of these novel compounds were elucidated to be (5R)-5-acetoxy-8,10,12-tetradecatriyne-1-O-beta-D-glucopyranoside, (2Z)-decaene-4,6,8-triyne-1-O-beta-D-glucopyranoside, (8Z)-1-[(3-O-beta-D-glucosyl)-isovaleroyloxy]-8-decaene-4,6-diyne, (8Z)-decaene-1-isovaleroyloxy-4,6-diyne-10-O-beta-D-glucopyranoside, and (2E,8E)-decadiene-4,6-diyne-1-O-beta-D-glucopyranoside via spectroscopic and chemical methods. All of the isolated compounds were tested for cytotoxicity against cancer cell lines, antibacterial activity, and inhibitory effects on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production. The results showed that (5R)-5-acetoxy-8,10,12-tetradecatriyne-1-O-beta-D-glucopyranoside significantly inhibited LPS-induced NO production in RAW264.7 cells in a dose-dependent manner.
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