Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep

Obtundation of wakefulness caused by opioids and loss of wakefulness caused by anesthetics and sleep significantly alter concentrations of molecules comprising the prefrontal cortex (PFC) metabolome. Quantifying state-selective changes in the PFC metabolome is essential for advancing functional metabolomics. Diverse functions of the PFC suggest the PFC metabolome as a potential therapeutic entry point for countermeasures to state-selective autonomic dysfunction.

Automated summary

Changes in wakefulness caused by opioids, anesthetics, and sleep alter concentrations of molecules in the prefrontal cortex (PFC) metabolome. It is crucial to quantify state-selective changes in the PFC metabolome for advancing functional metabolomics. The diverse functions of the PFC indicate its metabolome as a potential therapeutic target for counteracting state-selective autonomic dysfunction.