期刊
PHYSIOLOGY
卷 36, 期 6, 页码 367-381出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00026.2021
关键词
controlled release; depot; drug delivery; elastin-like polypeptide; nanoparticle
类别
资金
- National Institutes of Health (NIH) [R01HL121527, R01HL095638, R41DK109737]
ELPs are bioengineered proteins with a unique physical property of a thermally triggered inverse phase transition, which can be utilized for drug delivery. ELP-fusion proteins have various applications, such as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots, making them a promising platform for the development of biologics.
Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.
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