Transport and dynamic analysis of magnetic nanoparticles in brain microvascular vessels

The number of patients with neurodegenerative disorders is growing rapidly, and it poses a major concern to discover effective therapies. The well-known deep brain stimulation as a treatment for Parkinson's disease has irredeemable impact on the brain tissue. Magnetothermal stimulation is a good alternative though, it is still invasive due to stereotactic injection for nanoparticle delivery. A good solution to this issue is to take advantage of microvasculature and excite the nanoparticles inside the brain capillaries. Hence, transport and dynamic analysis of blood flow through a brain capillary is crucial. This article presents a two-dimensional theoretical study of a blood flow with magnetic nanoparticles through a capillary when exposed to an alternating magnetic field. The magnetic nanoparticles are localized within the domain over time. The particle transport impacts and the dynamic interactions with the blood flow are elaborately investigated.

Automated summary

As the number of patients with neurodegenerative disorders continues to grow, finding effective therapies becomes a major concern. Utilizing magnetothermal stimulation to activate nanoparticles within brain capillaries may offer a non-invasive treatment option. This article presents a theoretical study on the transport and dynamic interactions of blood flow with magnetic nanoparticles through a brain capillary.