期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 66, 期 15, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6560/ac0ea3
关键词
automation; position uncertainties; anatomical barriers; clinical target volume; fast marching method
资金
- Therapy Imaging Program (TIP) - Federal Share of program by Massachusetts General Hospital, Proton Therapy Research and Treatment Center [C06 CA059267]
This paper addresses the issue of handling uncertainties in positions of anatomical barriers in defining the clinical target volume (CTV). An algorithm was developed to implement consensus guidelines by performing multiple expansions using the fast marching method with barriers in place or removed at different stages of the expansion. The algorithm was validated in a computational phantom, comparing manually generated with automated CTV contours while considering barrier uncertainties.
The definition of the clinical target volume (CTV) is becoming the weakest link in the radiotherapy chain. CTV definition consensus guidelines include the geometric expansion beyond the visible gross tumor volume, while avoiding anatomical barriers. In a previous publication we described how to implement these consensus guidelines using deep learning and graph search techniques in a computerized CTV auto-delineation process. In this paper we address the remaining problem of how to deal with uncertainties in positions of the anatomical barriers. The objective was to develop an algorithm that implements the consensus guidelines on considering barrier uncertainties. Our approach is to perform multiple expansions using the fast marching method with barriers in place or removed at different stages of the expansion. We validate the algorithm in a computational phantom and compare manually generated with automated CTV contours, both taking barrier uncertainties into account.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据