4.8 Article

Elastic Instabilities Govern the Morphogenesis of the Optic Cup

期刊

PHYSICAL REVIEW LETTERS
卷 127, 期 13, 页码 -

出版社

AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.127.138102

关键词

-

资金

  1. National Science Foundation [CMMI-1824882]

向作者/读者索取更多资源

The study reveals that elastic instabilities play a crucial role in the morphogenesis of the eye during development, especially in the formation of the optic cup. If the optic vesicle is too slender, it may cause buckling and break axisymmetry, thus hindering normal development.
Because the normal operation of the eye depends on sensitive morphogenetic processes for its eventual shape, developmental flaws can lead to wide-ranging ocular defects. However, the physical processes and mechanisms governing ocular morphogenesis are not well understood. Here, using analytical theory and nonlinear shell finite-element simulations, we show, for optic vesicles experiencing matrix-constrained growth, that elastic instabilities govern the optic cup morphogenesis. By capturing the stress amplification owing to mass increase during growth, we show that the morphogenesis is driven by two elastic instabilities analogous to the snap through in spherical shells, where the second instability is sensitive to the optic cup geometry. In particular, if the optic vesicle is too slender, it will buckle and break axisymmetry, thus, preventing normal development. Our results shed light on the morphogenetic mechanisms governing the formation of a functional biological system and the role of elastic instabilities in the shape selection of soft biological structures.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据