VEGF aptamer/i-motif-based drug co-delivery system for combined chemotherapy and photodynamic therapy

Article Engineering, Environmental

DNA nanotechnology: A recent advancement in the monitoring of microcystin-LR

Tiying Suo et al.

Summary: This article introduces state-of-the-art analytical methods for the detection of MC-LR based on DNA nanotechnology and provides critical perspectives on the challenges and development in this field.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Review Biochemistry & Molecular Biology

The Molecular Tete-a-Tete between G-Quadruplexes and the i-motif in the Human Genome

Pallabi Sengupta et al.

Summary: This review addresses the importance of G-quadruplex and i-motif structures in duplex formation, discussing their dynamic interplay and their impact on cellular homeostasis and carcinogenesis. Insights into the spatiotemporal formation of these structures are provided, offering potential for designing reporter systems and diagnostic platforms for bioanalytical and therapeutic intervention.

CHEMBIOCHEM (2021)

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Review Chemistry, Medicinal

The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

Susie L. Brown et al.

Summary: The i-motif is a dynamic secondary DNA structure rich in cytosine, with potential as a molecular switch for gene expression control. It may play a role in facilitating or hindering expansion of DNA elements in genomic areas with repetitive nucleotide sequences. Recent discoveries, including the identification of a specific i-motif antibody, are advancing the field of i-motif research.

PHARMACEUTICALS (2021)

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Review Nanoscience & Nanotechnology

Functional Aptamer-Embedded Nanomaterials for Diagnostics and Therapeutics

Sitao Xie et al.

Summary: The combination of nanomaterials and aptamers holds great potential in bioapplications, especially in the fields of diagnostics and therapeutics, with important applications in cellular analysis, imaging, targeted drug delivery, and cancer diagnosis/therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Spectroscopy

Study of alkaloid berberine and its interaction with the human telomeric i-motif DNA structure

R. Gargallo et al.

Summary: Berberine interacts weakly with the i-motif formed by the human telomere, mainly through electrostatic interactions. The ligand is not selective for i-motif structures, binding equally to folded and unfolded strands without stabilizing the i-motif structure. The development of analytical methods involving fluorescent ligands should consider thermodynamic aspects and selectivity towards different DNA structures.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Review Chemistry, Multidisciplinary

Nuclease resistance of DNA nanostructures

Arun Richard Chandrasekaran

Summary: DNA nanotechnology has advanced from structural design to application-oriented research, facing challenges such as susceptibility to nuclease attack in biological applications. Recent strategies have been developed to enhance nuclease resistance of DNA nanostructures, with studies focusing on stability in biological fluids.

NATURE REVIEWS CHEMISTRY (2021)

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Review Medical Laboratory Technology

The use of aptamers in prostate cancer: A systematic review of theranostic applications

Esther Campos-Fernandez et al.

Summary: Aptamers have the potential to be more effective diagnostic and therapeutic tools in the field of prostate cancer, particularly in blood-based liquid biopsies and electro-analytical methods. However, while they show clinical promise, the development of these strategies is still in its early stages.

CLINICAL BIOCHEMISTRY (2021)

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Article Electrochemistry

Aptamers in biomedicine: Selection strategies and recent advances

Geanina Stefan et al.

Summary: Aptamers have emerged as bio-mimetic molecular recognition elements in biomedicine, with various applications in diagnostics, drug delivery, therapeutics, and pharmaceutical analysis. Despite their advantages, there are challenges to be addressed, such as poor specificity and sensitivity, questionable clinical use, low drug loading, in vivo stability, and toxicity. Further technological advances and research are needed to fully realize the potential of aptamers in the biomedical field.

ELECTROCHIMICA ACTA (2021)

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Article Chemistry, Physical

It's what's on the inside that counts: Techniques for investigating the uptake and recycling of nanoparticles and proteins in cells

Laura I. FitzGerald et al.

Summary: The review discusses current approaches for measuring the cellular uptake of nanoparticles and proteins, with a focus on recent advances in sensor technology. It highlights the requirements for quantifying internalization and potential pitfalls in data analysis. The importance of understanding recycling of internalized material back to the cell surface and methods for quantifying this process are also explored.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Biomedical

Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

Ping Wu et al.

Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.

BIOACTIVE MATERIALS (2021)

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Review Nanoscience & Nanotechnology

Multifunctional biomolecule nanostructures for cancer therapy

Jing Wang et al.

Summary: This review discusses the application of biomolecule-based nanostructures in smart cancer nanomedicine. These multifunctional nanostructures, including polysaccharides, nucleic acids, peptides, and proteins, can achieve targeted drug delivery and transport drugs to tumor tissues.

NATURE REVIEWS MATERIALS (2021)

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Review Oncology

Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy

Olivia A. Diaz Arguello et al.

Summary: Cancer, a complex disease marked by evasion of apoptosis, can potentially be treated by inducing apoptosis in cancerous cells. Among the tumor necrosis factor (TNF) protein family, certain ligands possess apoptosis-inducing capabilities. Various recombinant TNF apoptosis-inducing ligands have been developed over time to improve their effectiveness in cancer treatment.

CANCERS (2021)

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Review Cell Biology

Targeting the VEGF Pathway in Osteosarcoma

Tarek Assi et al.

Summary: Osteosarcoma is the most common primary tumor of the bones in young adults, with poor prognosis in relapsed or metastatic cases. However, advancements in targeted therapy, particularly focusing on angiogenesis, have shown promise in enhancing anti-tumor activity in osteosarcoma patients.

CELLS (2021)

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Review Cell Biology

Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options

Josh O. Wallsh et al.

Summary: This article reviews the central role of anti-vascular endothelial growth factor (anti-VEGF) therapy in treating various retinal diseases, as well as the subset of patients who do not respond effectively. It also discusses alternative treatment options for these cases and future research directions for anti-VEGF-resistant eyes.

CELLS (2021)

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Review Reproductive Biology

Mechanisms of doxorubicin-mediated reproductive toxicity-A review

Uma Priya Mohan et al.

Summary: Doxorubicin, an anticancer drug, induces reproductive toxicity in both males and females by causing testicular mass reduction, chromosome abnormalities, hormonal imbalance, and disrupting the normal physiological roles of reproductive cells. The drug also affects lipid metabolism, oxidative stress, and hormone levels in the reproductive system, leading to dysfunction in both male and female reproductive functions.

REPRODUCTIVE TOXICOLOGY (2021)

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Review Medicine, General & Internal

Visual Outcome after Intravitreal Anti-VEGF Therapy for Macular Neovascularisation Secondary to Sorsby's Fundus Dystrophy: A Systematic Review

Arthur Baston et al.

Summary: Analysis of 14 publications and one case report showed that immediate anti-VEGF treatment after symptom onset in MNV secondary to SFD resulted in favorable responses. Visual acuity worsened in some cases post-treatment, while others improved significantly or remained stable.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Materials Science, Multidisciplinary

Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications

Zike Huang et al.

Summary: DNA is not only important for biological roles, but also considered as an excellent engineering material with high programmability and addressability. Recent advances in DNA nano technology have enabled the design and fabrication of exquisite DNA nanostructures, providing new opportunities for technological uses. The integration of DNA nanostructures with aptamers, short single-stranded nucleic acids with molecular recognition capacity, has led to the development of powerful tools for advanced biological and biomedical applications.

MATTER (2021)

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Review Biochemistry & Molecular Biology