期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 34, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2021.102293
关键词
HPV; 5-aminolaevulinic acid; Photodynamic therapy; Cervix; Cervical intraepithelial neoplasia
类别
资金
- National Key RAMP
- D Program of China [2016YFC1302900]
- Project of Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20161412]
- Science and Technology Commission of Shanghai Municipality [18411963100]
- Key Discipline Project of Shanghai Municipal Commission of Health and Family Planning [15GWZK0701]
- Program of Shanghai Hospital Development Center [16CR2001A]
- Clinical Development Fund of Renji Hospital, School of Medicine, Shanghai Jiaotong University [PY2018IIA03]
- Shanghai Municipal Commission of Health and Family Planning [2017ZZ02016]
The study showed that ALA-PDT is effective in eliminating cervical hrHPV infection in HPV-positive women without cervical lesions. HPV16/18 positive cases benefit the most from ALA-PDT. Women infected with multiple types of HPV require more sessions of ALA-PDT to eradicate hrHPV infection.
Background: High-risk HPV (hrHPV) not only increases the risk of cervical precancerous lesions and cervical cancer, but also adds psychological burden to HPV-positive women. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive and highly tissue-selective therapy. We aim to investigate the clinical efficacy of ALA-PDT for elimination of cervical hrHPV infection in HPV-positive women without cervical lesions. Methods: A total of 57 hrHPV-positive women without pathologically proved cervical lesions received three treatments of ALA-PDT in total. HPV DNA testing and pap cytology were performed in all patients. Patients with positive HPV16/18 or abnormal TCT results received colposcopic biopsy during the follow-up. Results: hrHPV clearance rate was 56.1 % (32/57) at 3-month follow-up and 68.1 % at 6-month follow-up. 100 % of HPV 18 and 87.5 % of HPV16 infections were cleared while the clearance rate was 48.8 % among those positive for 12 other high-risk types. Multivariate analysis showed HPV16/18 infection was associated with significantly higher clearance rate. HPV clearance rate in patients with multiple-type HPV infection was significantly lower than that in patients with single-type HPV infections. Conclusions: ALA-PDT is effective on treating hrHPV infection in patients with no cervical lesions. HPV16/18 positive cases can benefit most from ALA-PDT. Multitype-infected women need more sessions of 5- ALA-PDT to eradicate hrHPV infection.
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