期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 34, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2021.102266
关键词
Melanoma; Dermoscopy; Reflectance confocal microscopy; Optical coherence tomography; Multiphoton excited fluorescence imaging; Stepwise two-photon excited fluorescence
类别
资金
- Shanghai Municipal Education Commission [20152227]
- Shanghai Municipal Science and Technology Commission [18XD1423700]
- National Natural Science Foundation of China [81772098]
- 9th People's Hospital, Shanghai Jiao Tong University School of Medicine [2017-1-007]
Cutaneous melanoma is a common malignancy with increasing incidence, emphasizing the importance of early diagnosis for patient survival. Innovative optical technologies have been developed to improve non-invasive melanoma diagnosis accuracy, but further research and improvement are needed. These technologies show promise in facilitating melanoma diagnosis, but aspects such as diagnostic accuracy, detection time, portability, and cost-effectiveness still require enhancement.
Cutaneous melanoma is one of the most common malignancies with increased incidence in the past few decades, making it a significant public health problem. The early diagnosis of melanoma is a major factor in improving patient's survival. The traditional pathway to melanoma diagnosis starts with a visual diagnosis, followed by subsequent biopsy and histopathologic evaluation. Recently, multiple innovative optical technology-based methods, including dermoscopy, reflectance confocal microscopy, optical coherence tomography, multiphoton excited fluorescence imaging and stepwise two-photon excited fluorescence (dermatofluoroscopy), have been developed to increase the diagnostic accuracy for the non-invasive melanoma diagnosis. Some of them have already been applied to real-life clinical settings, others require more research and development. These technologies show promise in facilitating the diagnosis of melanoma since they are non-invasive, sensitive, objective and easy to apply. Diagnostic accuracy, detection time, portability and the cost-effectiveness of the device are all aspects that need to be improved. This article reviews the method of these emerging optical non-invasive diagnostic technologies, their clinical application, their benefits and limitations, as well as their possible future development.
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