期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 97, 期 6, 页码 1453-1455出版社
WILEY
DOI: 10.1111/php.13485
关键词
-
资金
- National Science Foundation [CHE-1856765]
The article discusses the photolysis of a dibenzothiophene sulfoximine, producing reactive intermediates phenyl nitrene and atomic oxygen in tandem. Computational analysis reveals the labile nature of the S-N bond for nitrene release. The potential for future research to explore the release order of O(P-3) and nitrene from sulfoximine scaffolds, as well as the application of molecules with dual-intermediate release in photoaffinity labeling and cellular oxidation, is highlighted.
This article is a highlight of the paper by Isor et al. in this issue of Photochemistry and Photobiology. It describes the photolysis of a dibenzothiophene sulfoximine (bearing N-phenyl imino and S-oxide groups) to produce two reactive intermediates in tandem. The sulfoximine undergoes a S-N and S-O photocleavage to release phenyl nitrene and atomic oxygen [O(P-3)]. The phenyl nitrene dimerizes to azobenzene or is trapped by diethylamine to reach an azepine. From there, atomic oxygen arises in a secondary photolysis of dibenzothiophene sulfoxide. A computational analysis also reveals that the S-N bond is labile for initial nitrene release, with the secondary release of atomic oxygen by S-O cleavage. Whether future sulfoximine scaffolds can produce the reverse order release of O(P-3) then nitrene, or release both simultaneously, is yet to be established. Nonetheless, molecules with dual-intermediate release, such as coupled photoaffinity labeling and cellular oxidation, are worth pursuing.
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