期刊
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 79, 期 3, 页码 405-418出版社
WILEY
DOI: 10.1111/bcp.12268
关键词
bioequivalence; biopharmaceutics; drug formulations; paediatric; pharmacokinetics
资金
- National Institute for Health Research Medicines for Children Research Network
Paediatric formulation design is complex as there is a need to understand the developmental physiological changes that occur during childhood and their impact on the absorption of drugs. Paediatric dose adjustments are usually based on achieving pharmacokinetic or pharmacodynamic profiles equivalent to those achieved in adult populations. However, differences in the way in which children handle adult products or the use of bespoke paediatric formulations can result in unexpected pharmacokinetic drug profiles with altered clinical efficacy. Differences in drug formulations need to be understood by healthcare professionals involved in the prescribing, administration or dispensing of drugs to children such that appropriate advice is given to ensure that therapeutic outcomes are achieved. This issue is not confined to oral medicines but is applicable for all routes of administration encountered in paediatric therapy.
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