4.7 Review

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

α-Emitting cancer therapy using 211At-AAMT targeting LAT1

Kazuko Kaneda-Nakashima et al.

Summary: AMT has high affinity for LAT1, making At-211-AAMT a potential carrier for anti-cancer therapy by inhibiting tumor growth and inducing DNA double-stranded breaks. The accumulation of At-211-AAMT in vivo and its effectiveness in inhibiting tumor growth and metastasis suggest that At-211 could be useful for anti-cancer therapy, with LAT1 as a suitable target for radionuclide therapy.

CANCER SCIENCE (2021)

Article Oncology

Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

Hiroki Okanishi et al.

Summary: This study characterized the proteome and phosphoproteome in LAT1-inhibited cancer cells, revealing the broad influence of LAT1 inhibition on various functional pathways and key kinases. By comparing changes among cell lines, insights into general pathways and regulators associated with LAT1 inhibition were provided, with particular emphasis on cell cycle-related pathways and kinases. Additionally, the study evaluated the anticancer effects of combining LAT1 inhibitor with cell cycle-related kinase inhibitors, showing potential for cancer therapy.

CANCER SCIENCE (2021)

Article Genetics & Heredity

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Arafath K. Najumudeen et al.

Summary: Colorectal tumors with mutated KRAS and APC rely on the amino acid transporter SLC7A5 for tumorigenesis and enhanced protein synthesis. Targeting SLC7A5 could be an attractive approach for therapy-resistant KRAS-mutant colorectal cancer, as it plays a critical role in maintaining intracellular amino acid levels and supporting proliferation.

NATURE GENETICS (2021)

Article Cell Biology

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

Renhong Yan et al.

Summary: LAT1 is a representative light chain protein of heteromeric amino acid transporters, overexpressed in many types of tumors and considered a drug target for cancer treatment. The cryo-EM structures of LAT1-4F2hc complexes reveal an outward-facing occluded conformation and a different inhibition mechanism, providing important insights for future drug design.

CELL DISCOVERY (2021)

Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Pharmacology & Pharmacy

Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes

Chunhuan Jin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)

Article Cell Biology

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma

Yann Cormerais et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Multidisciplinary Sciences

Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex

Renhong Yan et al.

NATURE (2019)

Editorial Material Biochemistry & Molecular Biology

Insights into L-type heteromeric amino acid transporters

Simon Newstead

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Yongchan Lee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Pharmacology & Pharmacy

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Jussi Karkkainen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Biochemistry & Molecular Biology

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

Yann Cormerais et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Pharmacology & Pharmacy

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

Pornparn Kongpracha et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

Ryuichi Ohgaki et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Glutamine transporters in mammalian cells and their functions in physiology and cancer

Yangzom D. Bhutia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Chemistry, Medicinal

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

Arik A. Zur et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Biochemistry & Molecular Biology

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

Dora C. Tarlungeanu et al.

Article Oncology

LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma

Amy D. Marshall et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Article Biochemistry & Molecular Biology

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Mikko Gynther et al.

NEUROCHEMICAL RESEARCH (2016)

Article Multidisciplinary Sciences

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Shushi Nagamori et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Endocrinology & Metabolism

Expression and functional characterisation of System L amino acid transporters in the human term placenta

Francesca Gaccioli et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2015)

Article Multidisciplinary Sciences

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

Ruth Milkereit et al.

NATURE COMMUNICATIONS (2015)

Article Gastroenterology & Hepatology

Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma

Masashi Namikawa et al.

HEPATOLOGY RESEARCH (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

Aiko Nobusawa et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)

Review Biochemistry & Molecular Biology

The small SLC43 family: Facilitator system L amino acid transporters and the orphan EEG1

Susanna Bodoy et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Review Biochemistry & Molecular Biology

The ABCs of membrane transporters in health and disease (SLC series): Introduction

Matthias A. Hediger et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Review Biochemistry & Molecular Biology

The SLC3 and SLC7 families of amino acid transporters

Dimitrios Fotiadis et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior

Marina Poettler et al.

MOLECULAR CANCER (2013)

Review Biochemistry & Molecular Biology

Redox regulation in stem-like cancer cells by CD44 variant isoforms

O. Nagano et al.

ONCOGENE (2013)

Article Multidisciplinary Sciences

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

Ethan G. Geier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Oncology

Glucose transporters in cancer metabolism

Kehinde Adekola et al.

CURRENT OPINION IN ONCOLOGY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Transport of 3-Fluoro-L-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET

Pattama Wiriyasermkul et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Article Biochemistry & Molecular Biology

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

Ainara Elorza et al.

MOLECULAR CELL (2012)

Article Nutrition & Dietetics

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

Thomas D. Baird et al.

ADVANCES IN NUTRITION (2012)

Review Biochemistry & Molecular Biology

Leucine nutrition in animals and humans: mTOR signaling and beyond

Fengna Li et al.

AMINO ACIDS (2011)

Review Physiology

Biology of Human Sodium Glucose Transporters

Ernest M. Wright et al.

PHYSIOLOGICAL REVIEWS (2011)

Review Pharmacology & Pharmacy

Renal glucose reabsorption inhibitors to treat diabetes

Clifford J. Bailey

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Article Pharmacology & Pharmacy

Brain uptake of ketoprofen-lysine prodrug in rats

Mikko Gynther et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Article Biochemistry & Molecular Biology

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Paul Nicklin et al.

Review Urology & Nephrology

Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter

Benjamin Ko et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FMT Uptake Seen Within Primary Cancer on PET Helps Predict Outcome of Non-Small Cell Lung Cancer

Kyoichi Kaira et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Review Pharmacology & Pharmacy

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

Vadivel Ganapathy et al.

PHARMACOLOGY & THERAPEUTICS (2009)

Review Endocrinology & Metabolism

ATF4-dependent transcription mediates signaling of amino acid limitation

Michael S. Kilberg et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)

Article Pharmacology & Pharmacy

Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents

Ken-ichi Hosoya et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)

Article Pharmacology & Pharmacy

Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters

Emiko Morimoto et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

Differential uptake of O-(2-18F-fluoroethyl)-L-tyrosine, L-3H-methionine, and 3H-deoxyglucose in brain abscesses

Daumar Salber et al.

JOURNAL OF NUCLEAR MEDICINE (2007)

Article Radiology, Nuclear Medicine & Medical Imaging

Differentiation of tumour and inflammation:: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells

Barbara Stoeber et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2006)

Article Oncology

L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors

Hiroshi Nawashiro et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

Review Urology & Nephrology

Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters

Ignacio Gimenez

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2006)

Article Biochemical Research Methods

Metabolic activation-related CD147-CD98 complex

DS Xu et al.

MOLECULAR & CELLULAR PROTEOMICS (2005)

Review Oncology

Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?

BC Fuchs et al.

SEMINARS IN CANCER BIOLOGY (2005)

Article Pharmacology & Pharmacy

Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and caco-2 cells

TZ Su et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Biochemistry & Molecular Biology

Identification of LAT4, a novel amino acid transporter with system L activity

S Bodoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

CD98hc (SLC3A2) mediates integrin signaling

CC Feral et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption

SW Altmann et al.

SCIENCE (2004)

Article Physiology

CATs and HATs: the SLC7 family of amino acid transporters

F Verrey et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder

A Bröer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters

E Babu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Radiology, Nuclear Medicine & Medical Imaging

Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-L-tyrosine

D Pauleit et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2003)

Article Biochemistry & Molecular Biology

Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells

D Kim et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)

Article Radiology, Nuclear Medicine & Medical Imaging

O-(2-[18F]Fluoroethyl)-L-tyrosine (FET):: a tracer for differentiation of tumour from inflammation in murine lymph nodes

FC Rau et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2002)

Article Biochemistry & Molecular Biology

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

O Yanagida et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)

Article Neurosciences

The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier

T Kageyama et al.

BRAIN RESEARCH (2000)