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MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2006)
Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579
Elaine V. Hill et al.
CELLULAR SIGNALLING (2006)
Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline
Y. Bureau et al.
NEUROPHARMACOLOGY (2006)
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
Graeme B. Bolger et al.
BIOCHEMICAL JOURNAL (2006)
AKAP signaling complexes: getting to the heart of the matter
George McConnachie et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
HT Zhang et al.
PSYCHOPHARMACOLOGY (2006)
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
Debbie Willoughby et al.
EMBO JOURNAL (2006)
Preferential inhibition of human phosphodiesterase 4 by ibudilast
Z Huang et al.
LIFE SCIENCES (2006)
Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase
Q Huai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa
M Bajpai et al.
BIOLOGY OF REPRODUCTION (2006)
Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
Andrew T. Bender et al.
PHARMACOLOGICAL REVIEWS (2006)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
JK Millar et al.
SCIENCE (2005)
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias
SE Lehnart et al.
CELL (2005)
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase - A type II located in the centrosomal region
A McCahill et al.
CELLULAR SIGNALLING (2005)
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue
W Richter et al.
BIOCHEMICAL JOURNAL (2005)
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene
DA Wallace et al.
MOLECULAR PHARMACOLOGY (2005)
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
BJ Lipworth
LANCET (2005)
Vascular smooth muscle cell phenotype-dependent phosphodiesterase 4D short form expression: Role of differential histone acetylation on cAMP-regulated function
DG Tilley et al.
MOLECULAR PHARMACOLOGY (2005)
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex
JJC Michel et al.
BIOCHEMICAL JOURNAL (2004)
Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-{2-(3,4-bis-difluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor
D Claveau et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases
W Richter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines
AL Asirvatham et al.
JOURNAL OF IMMUNOLOGY (2004)
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process
R Terry et al.
CELLULAR SIGNALLING (2003)
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
S Gretarsdottir et al.
NATURE GENETICS (2003)
Role of the hyperpolarization-activated cation current (Ih) in pacemaker activity in area postrema neurons of rat brain slices
M Funahashi et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7
DG Wang et al.
CELLULAR SIGNALLING (2003)
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2
GB Bolger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Three-dimensional structures of PDE4D in complex with roliprams on inhibitor selectivity
Q Huai et al.
STRUCTURE (2003)
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
MD Houslay et al.
BIOCHEMICAL JOURNAL (2003)
Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294
DD Gale et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2003)
Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study
X Miró et al.
NEUROPHARMACOLOGY (2002)
Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V111294A in healthy volunteers
DD Gale et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Targeting of cyclic AMP degradation to β2-adrenergic receptors by β-arrestins
SJ Perry et al.
SCIENCE (2002)
Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs)
W Richter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Crystal structure of phosphodiesterase 4D and inhibitor complex
ME Lee et al.
FEBS LETTERS (2002)
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
A Robichaud et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells -: Identification and characterization of a novel PDE4D5 promoter
IR Le Jeune et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization
X Miró et al.
SYNAPSE (2002)
TAPAS-1, a novel microdomaln within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid
GS Baillie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
SJ MacKenzie et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting
MB Beard et al.
CELLULAR SIGNALLING (2002)
Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons
C D'Sa et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Assessing the emetic potential of PDE4 inhibitors in rats
A Robichaud et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
S Lamontagne et al.
BRAIN RESEARCH (2001)
Purification and characterization, of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells
PL Lario et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors
S Liu et al.
BIOCHEMISTRY (2001)
Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study
CH Compton et al.
LANCET (2001)
Phosphodiesterase 4D and protein kinase A type II constitute a signaling unit in the Centrosomal Area
KA Taskén et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10
G Rena et al.
MOLECULAR PHARMACOLOGY (2001)
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
KL Dodge et al.
EMBO JOURNAL (2001)
Myomegalin is a novel protein of the Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase
I Verde et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway
A Robichaud et al.
NEUROPHARMACOLOGY (2001)
Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography -: Comparison with monkey and rat brain
S Pérez-Torres et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2000)
The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding -: Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site
M Grange et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases
GS Baillie et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-α
X Miró et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases -: The involvement of COOH-terminal docking sites and NH2-terminal UCR regions
SJ MacKenzie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Conformational difference between PDE4 apoenzyme and holoenzyme
F Laliberté et al.
BIOCHEMISTRY (2000)
UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions
MB Beard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Docking domains and substrate-specificity determination for MAP kinases
AD Sharrocks et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
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