4.7 Review

Functionally selective and biased agonists of muscarinic receptors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Allosteric coupling and biased agonism in G protein-coupled receptors

Andreas Bock et al.

Summary: Bias agonism in GPCRs is likely a result of preferential allosteric coupling from the ligand binding pocket to a specific transducer, leading to selective activation of desired signaling pathways and potentially reducing side effects.

FEBS JOURNAL (2021)

Article Pharmacology & Pharmacy

Novel M2-selective, Gi-biased agonists of muscarinic acetylcholine receptors

Alena Randakova et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Chemistry, Medicinal

Agonist-Specific Conformations of the M2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics

Alena Randakova et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

Article Chemistry, Medicinal

Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling

Janine Holze et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)

Review Cell Biology

The structural basis of the arrestin binding to GPCRs

Vsevolod V. Gurevich et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Review Neurosciences

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

Sachchida Nand Rai et al.

NEUROTOXICITY RESEARCH (2019)

Review Pharmacology & Pharmacy

Biased Receptor Signaling in Drug Discovery

Terry Kenakin

PHARMACOLOGICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

Shoji Maeda et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Crystal structure of the M5 muscarinic acetylcholine receptor

Ziva Vuckovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biology

Common activation mechanism of class A GPCRs

Qingtong Zhou et al.

Article Pharmacology & Pharmacy

Novel long-acting antagonists of muscarinic ACh receptors

Alena Randakova et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622

Jason M. Uslaner et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

Article Pharmacology & Pharmacy

Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors

Anita K. Nivedha et al.

MOLECULAR PHARMACOLOGY (2018)

Review Biotechnology & Applied Microbiology

Biased signalling: from simple switches to allosteric microprocessors

Jeffrey S. Smith et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Editorial Material Cell Biology

Arrestins as rheostats of GPCR signalling

J. Silvio Gutkind et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Neurosciences

A mechanistic review on GNAO1-associated movement disorder

Huijie Feng et al.

NEUROBIOLOGY OF DISEASE (2018)

Review Cell Biology

Distribution and function of the muscarinic receptor subtypes in the cardiovascular system

Hannah C. Saternos et al.

PHYSIOLOGICAL GENOMICS (2018)

Article Multidisciplinary Sciences

Lack of beta-arrestin signaling in the absence of active G proteins

Manuel Grundmann et al.

NATURE COMMUNICATIONS (2018)

Review Cell Biology

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Denise Wootten et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Manifold roles of beta-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Louis M. Luttrell et al.

SCIENCE SIGNALING (2018)

Article Chemistry, Medicinal

Structure-Based Design and Discovery of New M2 Receptor Agonists

Inbar Fish et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling

Yuri K. Peterson et al.

PHARMACOLOGICAL REVIEWS (2017)

Article Evolutionary Biology

Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

Henrike Indrischek et al.

BMC EVOLUTIONARY BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor

Marcel Bermudez et al.

ACS CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Cholinergic system and cell proliferation

F. J. Campoy et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Article Pharmacology & Pharmacy

Allosteric communication pipelines in G-protein-coupled receptors

Nagarajan Vaidehi et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

Article Multidisciplinary Sciences

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

David M. Thal et al.

NATURE (2016)

Article Multidisciplinary Sciences

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction

Sophie J. Bradley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Pharmacology & Pharmacy

Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms

Alena Randakova et al.

PHARMACOLOGICAL RESEARCH (2015)

Review Pharmacology & Pharmacy

Novel GPCR paradigms at the μ-opioid receptor

G. L. Thompson et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Chemistry, Multidisciplinary

Position of Transmembrane Helix 6 Determines Receptor G Protein Coupling Specificity

Alexander S. Rose et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Chemistry, Multidisciplinary

A Brief History of G-Protein Coupled Receptors (Nobel Lecture)

Robert J. Lefkowitz

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Multidisciplinary Sciences

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Andrew C. Kruse et al.

NATURE (2013)

Review Pharmacology & Pharmacy

GPCR activation: a mutagenic spotlight on crystal structures

Edward C. Hulme

TRENDS IN PHARMACOLOGICAL SCIENCES (2013)

Article Biochemistry & Molecular Biology

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin et al.

ACS CHEMICAL NEUROSCIENCE (2012)

Review Biochemistry & Molecular Biology

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

B. Trzaskowski et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor

Karen J. Gregory et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Kazuko Haga et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Andrew C. Kruse et al.

NATURE (2012)

Article Multidisciplinary Sciences

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Andreas Bock et al.

NATURE COMMUNICATIONS (2012)

Article Chemistry, Medicinal

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

Evan P. Lebois et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Pharmacology & Pharmacy

Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

J. Jakubik et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Multidisciplinary Sciences

Subtype Differences in Pre-Coupling of Muscarinic Acetylcholine Receptors

Jan Jakubik et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

Benoit Poulin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Pharmacology & Pharmacy

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

Caline S. Karam et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2010)

Article Pharmacology & Pharmacy

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

C. J. Langmead et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Pharmacology & Pharmacy

G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists

Rachel L. Thomas et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Review Pharmacology & Pharmacy

Muscarinic acetylcholine receptors as CNS drug targets

Christopher J. Langmead et al.

PHARMACOLOGY & THERAPEUTICS (2008)

Article Pharmacology & Pharmacy

Estimation of agonist activity at G protein-coupled receptors:: Analysis of M2 muscarinic receptor signaling through Gi/o, Gs, and G15

Michael T. Griffin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Article Multidisciplinary Sciences

Targeting of diacylglycerol degradation to M1 muscarinic receptors by β-arrestins

Christopher D. Nelson et al.

SCIENCE (2007)

Article Pharmacology & Pharmacy

Functional selectivity and classical concepts of quantitative pharmacology

Jonathan D. Urban et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Article Pharmacology & Pharmacy

Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor

MKO Grant et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Biochemistry & Molecular Biology

AF150(S) and AF267B - M1 muscarinic agonists as innovative therapies for Alzheimer's disease

A Fisher et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2002)

Article Pharmacology & Pharmacy

Discovery of an ectopic activation site on the M1 muscarinic receptor

TA Spalding et al.

MOLECULAR PHARMACOLOGY (2002)

Article Pharmacology & Pharmacy

Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor

J Jakubík et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Review Immunology

Use of muscarinic agonists in the treatment of Sjogren's syndrome

RI Fox et al.

CLINICAL IMMUNOLOGY (2001)

Article Multidisciplinary Sciences

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

LM Luttrell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)