期刊
PHARMACOLOGICAL RESEARCH
卷 173, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105909
关键词
Gut microbiome; Microbiome-gut-brain axis; Neuropsychiatric disorders; HPA axis; Neurodevelopment; Neuroglia; Neuroinflammation
资金
- National Key R&D Program of China, China [2018YFC1311600]
- National Natural Science Foundation of China, China [81871070, 31971078, 81971276]
- Jilin Science and Technology Agency funds in China, China [20200301005RQ, 20190701078GH]
- Scientific Research Foundation of the Education Department of Jilin Province [JJKH20201032KJ]
Increasing evidence suggests that dysbiosis of gut microbiota may be involved in the physiological mechanisms of neuropsychiatric disorders, but the exact pathways are still unclear. The complex crosstalk between neuroendocrine and immunological regulation may underlie the mechanisms by which gut microbiota are associated with neuropsychiatric disorders.
Recently, increasing evidence has shown gut microbiota dysbiosis might be implicated in the physiological mechanisms of neuropsychiatric disorders. Altered microbial community composition, diversity and distribution traits have been reported in neuropsychiatric disorders. However, the exact pathways by which the intestinal microbiota contribute to neuropsychiatric disorders remain largely unknown. Given that the onset and progression of neuropsychiatric disorders are characterized with complicated alterations of neuroendocrine and immunology, both of which can be continually affected by gut microbiota via microbiome-gut-brain axis. Thus, we assess the complicated crosstalk between neuroendocrine and immunological regulation might underlie the mechanisms of gut microbiota associated with neuropsychiatric disorders. In this review, we summarized clinical and preclinical evidence on the role of the gut microbiota in neuropsychiatry disorders, especially in mood disorders and neurodevelopmental disorders. This review may elaborate the potential mechanisms of gut microbiota implicating in neuroendocrine-immune regulation and provide a comprehensive understanding of physiological mechanisms for neuropsychiatric disorders.
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