期刊
PEDIATRIC NEUROLOGY
卷 120, 期 -, 页码 71-79出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pediatrneurol.2021.03.009
关键词
Clinical neurology; Epilepsy; Outcome research; Pediatric; Status epilepticus
资金
- Epilepsy Research Fund
- Epilepsy Foundation of America [EF-213583]
- American Epilepsy Society/Epilepsy Foundation of America Infrastructure Award
- Pediatric Epilepsy Research Foundation
In pediatric refractory status epilepticus patients, the time to first non-BZD ASM is shorter on weekends and holidays compared to weekdays, mainly driven by in-hospital onset status epilepticus.
Background: Time to treatment in pediatric refractory status epilepticus is delayed. We aimed to evaluate the influence of weekends and holidays on time to treatment of this pediatric emergency. Methods: We performed a retrospective analysis of prospectively collected observational data of pediatric patients with refractory status epilepticus. Results: We included 329 patients (56% males) with a median (p25 to p75) age of 3.8 (1.3 to 9) years. The median (p25 to p75) time to first BZD on weekdays and weekends/holidays was 20 (6.8 to 48.3) minutes versus 11 (5 to 35) minutes, P = 0.01; adjusted hazard ratio (HR) = 1.20 (95% confidence interval [CI]: 0.95 to 1.55), P = 0.12. The time to first non-BZD ASM was longer on weekdays than on weekends/ holidays (68 [42.8 to 153.5] minutes versus 59 [27 to 120] minutes, P = 0.006; adjusted HR = 1.38 [95% CI: 1.08 to 1.76], P = 0.009). However, this difference was mainly driven by status epilepticus with in hospital onset: among 108 patients, the time to first non-BZD ASM was longer during weekdays than during weekends/holidays (55.5 [28.8 to 103.5] minutes versus 28 [15.8 to 66.3] minutes, P = 0.003; adjusted HR = 1.65 [95% CI: 1.08 to 2.51], P = 0.01). Conclusions: The time to first non-BZD ASM in pediatric refractory status epilepticus is shorter on weekends/holidays than on weekdays, mainly driven by in-hospital onset status epilepticus. Data on what might be causing this difference may help tailor policies to improve medication application timing. (c) 2021 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据