期刊
PEDIATRIC NEPHROLOGY
卷 37, 期 2, 页码 443-448出版社
SPRINGER
DOI: 10.1007/s00467-021-05227-0
关键词
Hyponatremia; Electrolyte disorder; Maintenance fluid therapy; Isotonic fluid therapy
资金
- University of Oulu
- Alma and K A Snellman Foundation, Finland
- Foundation for Pediatric Research, Finland
- Academy of Finland
- Oulu University Hospital
The study found that in acutely ill children receiving moderately hypotonic fluid therapy in the emergency department, one child developed severe hyponatremia.
Background Hypotonic fluids have been associated with hospital-acquired hyponatremia. The incidence of life-threatening severe hyponatremia associated with hypotonic fluids has not been evaluated. Methods This was a population-based cohort study of 46,518 acutely ill children 15 years of age or under who visited the pediatric emergency department (ED) at Oulu University Hospital, Finland, between 2007 and 2017. We retrieved all electrolyte measurements from the comprehensive electronic laboratory system and reviewed medical records for all patients with severe hyponatremia. Results The overall occurrence of severe hyponatremia (serum sodium < 125 mmol/L) was found in 27 out of 46,518 acutely ill children (0.06%, 95% confidence interval 0.04-0.08%). After admission, severe hyponatremia developed in seven of 6,984 children receiving moderately hypotonic fluid therapy (0.1%, 95% confidence interval 0.04-0.2%), usually within 8 h of admission. All children who developed severe hyponatremia during hospitalization were severely ill. Conclusion In this register-based cohort study of children presenting to the ED, severe hyponatremia developed in one of 998 acutely ill children receiving moderately hypotonic fluid therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据