4.5 Article

Colorectal cancer with microsatellite instability: Right-sided location and signet ring cell histology are associated with nodal metastases, and extranodal extension influences disease-free survival

期刊

PATHOLOGY RESEARCH AND PRACTICE
卷 224, 期 -, 页码 -

出版社

ELSEVIER GMBH
DOI: 10.1016/j.prp.2021.153519

关键词

dMMR; MSI; Metastasis; ENE; Extracapsular; Colon; rectum

资金

  1. Associazione Italiana per la Ricerca sul Cancro (AIRC 5x1000) [12182]
  2. Fondazione Cariverona: Oncology Biobank Project 'Antonio Schiavi' [203885/2017]

向作者/读者索取更多资源

By studying the risk of nodal metastasization and prognostic factors in colorectal cancer with microsatellite instability, the study revealed the histological consistency between primary tumors and matched nodal metastases, with extranodal extension identified as the strongest prognostic variable in MSI-CRC with nodal metastasis. Additionally, factors such as right-sided location, pT4 stage, and signet-ring histology were found to be commonly associated with nodal metastasization in MSI-CRC.
Colorectal cancer (CRC) with microsatellite instability (MSI) accounts for 15-18 % of all CRCs and represents the category with the best prognosis. This study aimed at determining any possible clinical/pathological features associated with a higher risk of nodal metastasization in MSI-CRC, and at defining any possible prognostic moderators in this setting. All surgically resected CRCs of the last 20 years (mono-institutional series) with a PCRbased diagnosis of MSI, with and without nodal metastasis, have been retrieved for histological review, which was performed following WHO guidelines. Furthermore, the most important prognostic moderators have been investigated with a survival analysis. The study of 33 cases of MSI-CRCs with nodal metastasis highlighted a high fidelity of histology maintenance between primary tumors and matched nodal metastases. At survival analysis, the strongest prognostic variable in MSI-CRCs with nodal metastasis was the extranodal extension (multivariate analysis, HR: 14.4, 95 %CI: 1.46-140.9, p = 0.022). Furthermore, through a comparison between nodal positive (33 cases) and nodal negative (71 cases) MSI-CRCs, right-sided location (p < 0.0001), pT4 stage (p = 0.0004) and signet-ring histology (p = 0.0089) emerged as parameters more commonly associated with nodal metastasization. These findings shed new light on the biology of MSI-CRC and can be of help for the prognostic stratification of MSI-CRC patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据