期刊
OTOLOGY & NEUROTOLOGY
卷 42, 期 8, 页码 E1106-E1110出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAO.0000000000003207
关键词
Cerebellar flocculus; Vestibular schwannoma; Vestibular testing; Vestibulo-ocular reflex
The study investigated the impact of unilateral vestibular schwannoma on VOR function, finding both ipsilesional and contralesional VOR impairment in patients, with bilateral VOR impairment correlating with tumor size. Brainstem compression was associated with reduced ipsilesional VOR gain, but not contralesional VOR gain.
Impairment of ipsilesional vestibulo-ocular reflex (VOR) function is well described in vestibular schwannoma (VS) and a correlation between gain of the VOR and tumor size has been suggested. Bilateral VOR impairment may also occur in VS patients, but its mechanisms are poorly understood. We sought to explore the effect of unilateral VS on ipsilesional and contralesional high-acceleration VOR function using video head impulse testing, and evaluate potential factors responsible for contralesional VOR impairment. Materials and Methods: Chart review in tertiary referral center of patients with unilateral VS, who completed neurotological examination and vestibular function testing. Results: One hundred one patients (mean age 57.4 yrs) were included. Maximal tumor diameter ranged from 0.3 to 5.0 cm. Forty one patients had evidence of brainstem compression from VS on magnetic resonance imaging (MRI). Ipsilesional and contralesional VOR impairment was present in 81 (80%) and 44 (43%) patients, respectively. Bilateral VOR impairment was seen in 42 (42%) patients. Bilateral VOR impairment correlated with tumor size. Presence of brainstem compression was associated with reduced ipsilesional VOR gain, but not contralesional VOR gain.
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