期刊
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
卷 166, 期 2, 页码 297-304出版社
WILEY
DOI: 10.1177/01945998211024923
关键词
Caprini; venous thromboembolism; prevention; chemoprophylaxis; bleeding
The study aimed to modify the CRAM-based protocol for otolaryngology patients and evaluate the efficacy and safety. Among the 508 patients, only 1 developed deep vein thrombosis, with no cases of pulmonary embolism. The protocol adherence rate was 79% with an average follow-up time of 115 days. The results suggest that the novel protocol is effective and safe for VTE prevention in otolaryngology, though further validation through a larger-scale study is needed.
Objective Venous thromboembolism (VTE) is a preventable cause of postoperative morbidity and mortality. The Caprini risk assessment model (CRAM) is a validated tool for estimating the risk for postoperative VTE. Previous studies demonstrated a low risk of VTE among otorhinolaryngology-head and neck surgery (ORL-HNS). Hence, our objective was to modify the CRAM-based protocol to be applicable for otolaryngology patients and assess protocol efficacy and safety. Study Design Observational pilot study conducted on ORL-HNS patients undergoing surgery. Setting University-affiliated tertiary care center. Methods We constructed a modified protocol based on the CRAM and previous reports in the ORL-HNS literature using a reduced postoperative anticoagulation regimen. Primary end point was symptomatic VTE up to 3 months after surgery. Main secondary outcome was postoperative bleeding. Results A total of 508 patients were enrolled. Of them, 48% underwent head and neck surgery, 18% direct laryngoscopy and transoral robotic surgery, 15% endoscopic sinus surgery, and 11% otology surgery. Adherence to the protocol was 79%. Mean follow-up time was 115 days (range, 30-448 days). Only 1 patient developed deep vein thrombosis, and none developed pulmonary embolism. Two patients had major bleeding not related to the use of anticoagulation. Conclusions Our novel CRAM-based protocol appears to be efficacious and safe for VTE prevention in otolaryngology. A larger-scale study is required to validate these findings.
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