Synthesis of Biaryl Phosphine Palladium(0) Precatalysts

Well-defined palladium precatalysts have become increasingly important in cross-coupling chemistry. Despite the wide choice of complexes available today, palladium(0) compounds bearing Buchwald's biaryl phosphines are still under-represented. We present here an efficient and facile synthesis of biaryl phosphine palladium(0) complexes supported by a divinyltetramethyldisiloxane (dvtms) ligand. Starting from commercially available [Pd(allyl)Cl](2), a variety of [Pd(L)(dvtms)] complexes can be accessed in high yields under mild reaction conditions. Their catalytic activity was tested in Buchwald-Hartwig couplings and found to be very good for both (hetero)aryl bromides and chlorides.

Automated summary

This study presents an efficient synthesis method for biaryl phosphine palladium(0) complexes with dvtms ligands, which exhibit good catalytic activity in Buchwald-Hartwig couplings for (hetero)aryl bromides and chlorides.