Concise and Efficient Synthesis of [6]-Paradol

Y An efficient synthesis of [6]-paradol (1) has been performed in four steps with a 72.0% overall yield. The present method highlights commercially available materials, convenient isolation with multiple crystallization without involving column chromatography, and a high-purity product (more than 99.2%), and it is amenable to large-scale synthesis.

Automated summary

In this study, an efficient synthesis of [6]-paradol was achieved in four steps with a 72.0% overall yield. The method utilized commercially available materials and allowed for convenient isolation with multiple crystallization without the need for column chromatography, resulting in a high-purity product of over 99.2% purity that is suitable for large-scale synthesis.